Research Progress of circRNA and Its Significance in Forensic Science
10.3969/j.issn.1004-5619.2016.02.013
- VernacularTitle:circRNA的研究进展及其法医学意义
- Author:
Yaqi ZHANG
;
Chengchen SHAO
;
Chengtao LI
;
Ziqin ZHAO
;
Jianhui XIE
- Publication Type:Journal Article
- Keywords:
forensic genetics;
circR N A;
review [publication type
- From:
Journal of Forensic Medicine
2016;32(2):131-133
- CountryChina
- Language:Chinese
-
Abstract:
RNA has received m ore attention in the field of forensic m edicine and the developm ent of the new biological m arkers based on RNA show s great significance in the analysis of com plex cases. circular RNA (circRNA ) is a kind of non-coding RNA w hich is w idely reported recently. A lthough the regulatory m echanism s of generation and expression are not fully clear, the existing research indicates that circRNA has im portant biological functions. C ircRNA has a cell-type-specific expression w ith great stability and a high expression level, w hich m akes it m eaningful in forensic applications potentially. In this paper, the research progress, the generation and regulation of circRNA as w ell as its biological characteristics and functions are sum m arized, w hich w ill provide references for related studies and foren-sic applications.
