New Progress of MALDI-TOF-IMS in the Study of Proteomics
10.3969/j.issn.1004-5619.2016.02.012
- VernacularTitle:MALDI-TOF-IMS在蛋白质组学研究中的新进展
- Author:
Guanheng REN
;
Ronghua WENG
;
Yan SHI
;
Ping HUANG
;
Zhengdong LI
;
Yu SHAO
;
Kaifei DENG
;
Ningguo LIU
;
Yijiu CHEN
- Publication Type:Journal Article
- Keywords:
forensic pathology;
proteom ics;
review [publication type];
m ass spectrom etry;
m atrix-assisted laser desorption;
biological tissue section
- From:
Journal of Forensic Medicine
2016;32(2):126-130
- CountryChina
- Language:Chinese
-
Abstract:
Matrix-assisted laser desorption/ionization tim e-of-flight im aging m ass spectrom etry (MALDI-TOF-IMS ) has been a classical technique for studying proteom ics in present and a tool for analyzing the distribution of proteins and sm all m olecules w ithin biological tissue sections. MALDI-TOF-IMS can analyze m ultiple unknow n com pounds in biological tissue sections sim ultaneously through a single m ea-surem ent w hich can obtain m olecule im aging of the tissue w hile m aintaining the integrity of cellular and m olecules in tissue. In recent years, im aging m ass spectrom etry technique develops relatively quickly in all biom edical dom ain. T his paper based on the relevant data and review s the present developing level of MALDI-TOF-IMS, the principle of im aging m ass spectrom etry, m ethology and the prospect in foren-sic pathology.
