Association of SOX5 polymorphisms in chronic obstructive pulmonary disease-related pulmonary hypertension
10.3969/j.issn.1000-4718.2016.09.019
- VernacularTitle:SOX5基因多态性与慢性阻塞性肺疾病及并发症肺动脉高压的关联性分析
- Author:
Bing ZHUAN
;
Ling HE
;
Yuting LU
;
Ping LI
;
Xia ZHAO
;
Guohui QIU
;
Nan MA
;
Wei MA
;
Zhao YANG
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Pulmonary hypertension;
SOX5 gene;
Single nucleotide polymorphisms
- From:
Chinese Journal of Pathophysiology
2016;32(9):1648-1652
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the differences in the distribution of SRY-related HMG box 5 (SOX5) gene single nucleotide polymorphisms (SNPs) among stable chronic obstructive pulmonary disease (COPD) patients, COPD with pulmonary hypertension (PH) patients and healthy controls, and to explore the association of the SOX5 SNPs in COPD-related PH.METHODS: From April 2013 to April 2015, 250 patients with stable COPD were enrolled continuous-ly in Ningxia People’s Hospital according to COPD treatment guidelines (2013 edition).All the patients received echocar-diography, and were divided into COPD with PH group [pulmonary artery systolic pressure (PASP)≥50 mmHg, n =103] and COPD without PH group (PASP <50 mmHg, n =147).The healthy persons (matched for age, sex, race and smoking index, n =127) were selected as control group at the same period.Genotyping of SOX5 gene rs10842262 and rs11046966
loci was performed using MassARRAY genotyping system ( Sequenom).Genotype frequencies were calculated.RE-SULTS: Age, sex and smoking index showed no significantly difference between control group and COPD group, neither between COPD with PH group and COPD without PH group.Genotype frequencies of SOX5 gene rs10842262 and rs11046966 loci between control group and COPD group was of significant difference (P<0.05).Genotype frequencies of SOX5 gene rs10842262 and rs11046966 loci showed no significant difference between COPD with PH group and COPD without PH group.CONCLUSION: SOX5 gene rs10842262 and rs11046966 loci may play an important role in COPD, but not in COPD-related PH.
