Effect of Metarhiziun taii polysaccharide on serum glucose and immune function of diabetic mellitus model mics
10.3969/j.issn.1000-484X.2016.09.020
- VernacularTitle:戴氏绿僵菌多糖对糖尿病模型小鼠血糖和免疫功能的影响
- Author:
Daimin XIAO
;
Jianhui XIAO
;
Yu CAO
;
Zhimin ZHANG
;
Min LIU
- Publication Type:Journal Article
- Keywords:
Metarhiziun taii;
Polysaccharide;
Diabetic mellitus model;
STZ
- From:
Chinese Journal of Immunology
2016;32(9):1338-1341
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Metarhiziun taii polysaccharide on the immunity activity of the diabetic mellitus model mouse.Methods:To build stables type Ⅰ diabetic model mouse by intraperitoneal injecting small dose streptozotocin ( STZ) continuously.Then observeing weight changes,detecting empty stomach serum glucose,immune organ index( include spleen and thymus),peritoneal macrophage phagocyte ability,spleen lymphocyte multiplication and immunoglobulin IgG′s and complement C3,C4 content in blood serum of the diabetic rats.Results:The weight of model mouse had been improved by Metarhiziun taii polysaccharide, serum glucose had been improved degrade of the ability of model mouse.T,B lymphocyte proliferation had been increased obviously by middle and high dose polysaccharid,spleen index,IgG′s and C3,C4 content in blood serum of the diabetic rats could be improved by high dose distinctively.Thymus index and the capacity of peritoneal macrophage phagocyte would enhanced by middle and high dose polysaccharide inject.Conclusion:The immune function and serum glucose of typeⅠdiabetic mode rats could be improved by intra-gastriced Metarhiziun taii polysaccharide.
