Characteristics of Vδ2 γδ T cells in patients with chronic hepatitis C
10.3969/j.issn.1000-484X.2016.09.022
- VernacularTitle:Vδ2γδ T细胞亚群在慢性HCV感染中的特征
- Author:
Wenwei YIN
;
Qiongfang ZHANG
;
Jianying SHAO
;
Shiwen TONG
- Publication Type:Journal Article
- Keywords:
HCV;
γδT cell;
Vδ2 T cell;
Viral titer;
ALT
- From:
Chinese Journal of Immunology
2016;32(9):1346-1349
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the role of γδ T cells and Vδ1 and Vδ2 T subsets played in patients with chronic hepatitis C.Methods:The percentage of peripheral bloodγδT cells and Vδ1 and Vδ2 T subsets cells was assessed by flow cytometry ( FACS) . Results:There were no significant differences in the percentage of circulating γδ T cells and Vδ1 and Vδ2 T subsets between HCV-infected patients and healthy controls ( HCs).However,The number of peripheral blood Vδ2 T cells from HCV-infected patients was positively correlated with serum alanine aminotransferase ( ALT) levels,but showed no correlation with serum HCV RNA.Peripheral Vδ2 T cells from HCV-infected patients were in activated status.The expression of CD107a was enhanced in Vδ2 T cells from HCV-infected patients compared to HCs.Conclusion:Vδ2 T cells were involved in liver injury in chronic HCV-infected patients.
