Study on senescence and proliferation of NKT like cells in HIV infected patients after antiviral therapy

VernacularTitle:抗病毒治疗后HIV感染者NKT样细胞衰老和体外增殖研究
Author: Xue ZHAO ; Tingting LIU ; Zining ZHANG ; Yajing FU ; Yongjun JIANG
Publication Type:Journal Article
Keywords: Human immunoddficiency virus; NKT like cells; Highly active antiretroviral therapy
From: Chinese Journal of Immunology 2016;32(9):1354-1356
CountryChina
Language:Chinese
Abstract: Objective:To better understand the changes of the NKT like cells after HIV infection and HAART treatment.Methods: Peripheral blood from HIV-infected individuals, HAART-treatment AIDS patients and healthy controls were collected, the expression of CD57 and the proliferation ability of NKT like cells before and after HAART were analyzed by flow cytometry.Results:We found that the percentage of NKT like cells before HAART was significantly lower than the healthy controls ( P<0.01 ) , and recovered after HAART treatment ( P<0.05 );the aging of NKT like cells was significantly higher before HAART compared with health individuals (P<0.01),and recovered after HAART treatment(P<0.05)the proliferation was significantly lower in vitro before HAART compared with healthy controls,and partial recovered after HAART.Conclusion: After HAART treatment,the number of NKT like cells,CD57 expression and the proliferation ability of HIV infected patients were restored.