Research advance of PDSS2 gene on carcinoma
10.3969/j.issn.1000-4718.2016.09.031
- VernacularTitle:PDSS2基因与肿瘤的研究进展
- Author:
Ting TONG
;
Wei HUANG
- Publication Type:Journal Article
- Keywords:
PDSS2 gene;
Tumor suppressor genes;
Carcinoma
- From:
Chinese Journal of Pathophysiology
2016;32(9):1713-1717
- CountryChina
- Language:Chinese
-
Abstract:
[ ABSTRACT] Prenyl diphosphate synthase subunit 2 ( PDSS2), which encodes the second subunit of prenyl diphosphate synthase, an essential enzyme involved in the biosynthesis of coenzyme Q10 (CoQ10), is almost expressed in all tissues and organs at different developmental stages of human beings.The abnormal expression of PDSS2 may result in many diseases through impacting the biosynthesis of CoQ10.Recent studies show that PDSS2 gene has decreased in mela-noma, gastric cancer, lung cancer and hepatocellular carcinoma, and the degree of reduced level is closely related to the clinical features, which enlighten us that PDSS2 maybe a tumor suppressor gene involves in the development and progres-sion of carcinoma.This review aims to introduce the recent research progress about PDSS2 gene on carcinoma, discuss its roles and value on cancer research.
