The protective effect of nuclear factor-E2-related factor 2 in secondary pancreatic injury in sepsis
10.3760/cma.j.issn.1673-4912.2016.08.011
- VernacularTitle:核因子E2相关因子2对脓毒症胰腺损伤保护作用的研究
- Author:
Haipeng YAN
;
Yimin ZHU
- Publication Type:Journal Article
- Keywords:
Sepsis;
Pancreatic injury;
Nuclear factor E2-related factor2
- From:
Chinese Pediatric Emergency Medicine
2016;23(8):552-555
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a major cause of secondra y pancreatic injury in critically ill children.A lagr e number of inflammatoyr m ediators werer elesa ed after acute ijn ury of the pancreas,which may aggravate the inflammatory reaction and the stress reaction.Nuclear factor E2-related factor 2(Nrf2),an important protec-tive transcription factor,could activate the expression of more than 500 genes.Most of the genes have the function of cytoprotection.Studise have dem onts rated that Nrf2 plays a certain role in cytoprotection,such as regulating the inflammatory response,anti-oxidative stress,improving mitochondrial functoi n and decreasing toxic protein aggregation.This review explored the protective mechanism of Nrf2 in pancreatic injury caused by sepis s.
