Value of premedication of pronase and simethicone for upper gastrointestinal endoscopy
10.3760/cma.j.issn.1007-5232.2016.07.009
- VernacularTitle:链霉蛋白酶联合西甲硅油乳剂在胃镜检查术前准备中的应用价值
- Author:
Aiqin LI
;
Peng JIN
;
Lang YANG
;
Haihong WANG
;
Xin WANG
;
Dongliang YU
;
Jianqiu SHENG
- Publication Type:Journal Article
- Keywords:
Gastroscopy;
Pronase;
Simethicone;
Visual fields
- From:
Chinese Journal of Digestive Endoscopy
2016;33(7):463-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of premedication of pronase and simethicone before upper gastrointestinal endoscopy. Methods A total of 4 690 patients undergoing upper gastrointestinal en?doscopy from January 2014 to November 2014 were recruited at gastrointestinal endoscopy center in Beijing Military General Hospital. All patients were randomized into 3 groups. The pronase plus simethicone group( n=1 602) took 40 ml mixed solution of pronase, sodium bicarbonate and simethicone orally 20 minutes before endoscopy. The simethicone group( n=1 548) took 40 ml simethicone orally 20 minutes before endoscopy. And the control group( n=1 540) took 10 ml lidocaine hydrochloride mucilage orally 5 minutes before endos?copy. The visibility during gastroscopy was observed. Results Each patient underwent gastroscopy, and no severe adverse event occurred during the procedure. The visibility of 82?3%( n=1 318) of the pronase plus simethicone group, 67?7%( n=1 048) of the simethicone group and 28?1% patients( n=432) of the control group respectively reached grade A or B. The visibility during gastroscopy in the pronase plus simethicone group was higher than that in the simethicone group(χ2=89?42, P=0?000) , while that in the simethicone group was higher than that of the control group(χ2=486?30, P=0?000). Conclusion Premedication of pronase and simethicone can improve the visibility during gastroscopy.
