Corin-serine protease and clinical applications in cardiovascular disease
10.3760/cma.j.issn.1009-9158.2016.09.002
- VernacularTitle:丝氨酸蛋白酶 Corin 在心血管疾病中的应用
- Author:
Xuejing HAN
;
Kegang JIA
- Publication Type:Journal Article
- Keywords:
Heart failure;
Cardiovascular diseases;
Serine endopeptidases;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2016;39(9):661-664
- CountryChina
- Language:Chinese
-
Abstract:
Corin is a newly identified membrance protease which responsible for converting pro-B-type natriuretic peptide to biologically active B-type natriuretic peptide.B-type natriuretic peptide play an important role in regulating blood pressure and cardiac function.It is a biological marker of heart failure.So Corin plays a role in reducing blood volume, blood pressure, regulating body fluid balance, and improving cardiac function.Corin may be used as a biomarker for heart failure or other cardiovascular disease.Recent studies have found that Corin is associated with the occurrence and development of cardiovascular diseases, such as heart failure and acute coronary syndrome.The article mainly expound the biological characteristics of Corin, testing methods and its clinical application in cardiovascular disease status.
