Progress on pharmacokinetics/pharmacodynamics of antimicrobial agents
10.3760/cma.j.issn.1674-2397.2016.04.008
- VernacularTitle:抗菌药物药代动力学／药效动力学研究进展
- Author:
Wei YU
;
Lihua GUO
;
Yunqing QIU
- Publication Type:Journal Article
- Keywords:
Antibacterials;
Antifungals;
Pharmacokinetics/Pharmacodynamics
- From:
Chinese Journal of Clinical Infectious Diseases
2016;9(4):321-329
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetics/pharmacodynamics ( PK/PD) of antimicrobials aims to establish and evaluate dose-concentration-response relationship, and subsequently to describe and predict the effect-time courses resulting from a drug dose.Nowadays, PK/PD is playing an important role in dosage regimen optimizing, reducing toxicity and drug tolerance of antibiotics.And it is also of great significance in determining susceptibility breakpoints and development in new drug.This paper reviews the progress on PK/PD studies of antibacterial and antifungal agents to provide theoretical basis for safe and effective individual dosage regimens.
