A study on the correlation between hypoxia and insulin resistance in males with metabolic syndrome
10.3760/cma.j.issn.1000-6699.2016.08.006
- VernacularTitle:男性代谢综合征患者中组织缺氧与胰岛素抵抗的相关性研究
- Author:
Sufeng CHEN
;
Jun XIA
;
Zhiming SHAN
;
Xiping YU
;
Qingfeng HU
;
Liannyu QIU
;
Yonglie ZHOU
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Hematological parameters;
Hypoxia;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
2016;32(8):652-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between hypoxia and insulin resistance in males with metabolic syndrome ( MS ). Methods Parameters at physical, hematological, glucose metabolism, lipid metabolism, and insulin resistance were measured in 295 middle-aged men who took health examination. The trends of laboratory indexes grouped by hemoglobin quartile and MS components were compared. The correlation between hypoxia and insulin resistance was analyzed. Results With the increase of hemoglobin, the occurrence rates of MS, TG, INS, and HOMA-IR were also significantly increased ( P < 0. 05 ), while HDL-C and HOMA-IS reduced remarkably(P<0. 05). With the increase of MS components, hematological parameters(RBC, Hb, Hct), INS, and HOMA-IR were significantly increased( P<0. 05) while HOMA-IS were significantly decreased( P<0. 05). Blood lactate and HIF-1αwere significantly increased with the increase of hemoglobin as well as MS components(P<0. 05);Hematological parameters were positively correlated with blood lactate and HIF-1α, and Hypoxia related indicators including hematological parameters, Lac, HIF-1α showed a positive correlation with HOMA-IR and a negative correlation with HOMA-IS( P < 0. 05). Conclusion Chronic hypoxia does exist in metabolic syndrome, and the degree of hypoxia is associated with insulin resistance. Hematological parameters are also significantly correlated with insulin resistance which could be as a result of chronic hypoxia.
