Therapeutic effect of hyperbaric oxygen therapy on patients with severe craniocerebral injury and its influence ;on serum interleukin -1 beta and interleukin -6 levels
10.3760/cma.j.issn.1008-6706.2016.19.017
- VernacularTitle:高压氧疗法对重型颅脑损伤患者的疗效及对血清白介素-1β和白介素-6水平的影响
- Author:
Yankai XU
;
Jin WU
;
Shaoling MA
;
Shengliang XU
;
Cheng LUO
- Publication Type:Journal Article
- Keywords:
Craniocerebral trauma;
Hyperbaric oxygenation;
Interleukin -1 beta;
Interleukin -6
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(19):2949-2952
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical curative effect of hyperbaric oxygen therapy for severe cranio-cerebral injury,and its influence on the level of serum interleukin -1 beta(IL -1 )and interleukin -6(IL -6). Methods 150 patients with severe craniocerebral injury were selected and divided into two groups by random and single blind method.75 patients of the control group were treated with conventional therapy,75 patients of the observation group were given hyperbaric oxygen on the basis of the conventional treatment,and the clinical efficacy was compared between the two groups.Results The total effective rate of the observation group was 94.67%,which was significantly higher than 77.33% of the control group,the difference was statistically significant(χ2 =7.83,P <0.05).There were no significant differences in GCS and ADL scores between the two groups(t =1.22,2.39,all P >0.05).After treat-ment,the GCS and ADL scores of the observation group were (12.18 ±2.13)points,(67.46 ±12.55)points,which were significantly higher than those before treatment(t =8.01,7.76,all P <0.05),and there were significant differ-ences between the two groups(t =7.23,6.82,all P <0.05).Before treatment,there were no significant differences in the serum levels of IL -6 and IL -1 between the two groups(t =2.10,1.01,all P >0.05).After treatment,the serum levels of IL -1 and IL -6 in the observation group were (127.48 ±16.35)pg/mL,(89.66 ±13.47)pg/mL, which were significantly lower than before treatment(t =8.34,7.89,all P <0.05),there were significant differences between the two groups(t =7.65,7.22,all P <0.05).Conclusion Implementation of hyperbaric oxygen in patients with severe traumatic brain injury on the basis of conventional symptomatic treatment can effectively improve the clinical symptoms and signs,reduce the serum IL -1 and IL -6 levels,promote the recovery of brain function and ability of daily life,and which is worth to be promoted in clinical.
