Prognostic value of combined detection cardiac troponin I and brain natriuretic peptide in plasma for patients ;with acute heart failure
10.3760/cma.j.issn.1008-6706.2016.19.036
- VernacularTitle:联合检测血浆肌钙蛋白Ⅰ和脑钠肽对急性心力衰竭患者严重程度及预后判断的价值
- Author:
Anwei YANG
;
Naiting CHEN
;
Chenglong XUE
- Publication Type:Journal Article
- Keywords:
Acute heart failure;
cTnⅠ;
BNP;
Severity;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(19):3018-3021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of combined detection of plasma BNP and cTnⅠin predicting the prognosis of patients with acute heart failure.Methods 88 patients with acute heart failure were selected in emergency department of our hospital.According to the outcomes of patients'condition,the patients were divided into improved and discharged group (n =58)and died group (n =30).And 50 healthy people were selected as control group during the same period in our hospital.The changes of cTnI and BNP levels in the three groups were compared and analyzed.Results Compared with the control group,in the improved and discharged group and died group,the levels of cTnI were (1.09 ±0.91)ng/mL and (3.07 ±1.35)ng/mL,the levels of BNP were (182.76 ± 34.19)pg/mL and (226.84 ±51.73)pg/mL,which were significantly increased,the differences were statistically significant (t =9.15,9.90,26.11,13.99,all P <0.05 ).Compared with the control group,the patients before discharge in improved and discharged group,the levels of cTnI and BNP were (0.09 ±0.05)ng/mL and (65.33 ± 20.61)pg/mL,which were increased,the differences were not statistically significant (t =1.35,0.83,all P >0.05). Compared with the control group,the patients before death in died group,the levels of cTnI and BNP were (4.38 ± 1.59)ng/mL and (254.39 ±62.81 )pg/mL,which were significantly increased,the differences were statistically significant (t =12.09,13.52,all P <0.05).Compared with the improved and discharged group,the patients in died group admitted to hospital and before death,the levels of cTnI and BNP were increased significantly,the differences were statistically significant (t =6.16,3.59,12.06,13.25,all P <0.05).Compared with the cardiac function in patients with grade Ⅲ,the cardiac function in patients with grade Ⅳ,the levels of cTnI increased significantly,the difference was statistically significant (t =6.64,P <0.05).Conclusion Combined detection cTnⅠ and BNP has a guiding value for the prognosis of patients with acute heart failure.It provides a reference for clinical treatment.
