Effects of Compound Uncaria Hypotensive Tablets on Expressions of MCP-1 and MMP-9 of Vascular Remodeling in Spontaneously Hypertensive Rats
10.3969/j.issn.1005-5304.2016.10.013
- VernacularTitle:复方钩藤降压片对自发性高血压大鼠血管重塑单核细胞趋化蛋白-1和基质金属蛋白酶-9表达的影响
- Author:
Jin FENG
;
Wen ZHANG
;
Jun QING
;
Huimin LIU
;
Yuansheng TAN
- Publication Type:Journal Article
- Keywords:
Compound Uncaria Hypotensive Tablets;
spontaneously hypertensive rats;
vascular remodeling;
MCP-1;
MMP-9
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(10):51-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Compound Uncaria Hypotensive Tablets on expressions of MCP-1 and MMP-9 of vascular remodeling in spontaneously hypertensive rats (SHR); To discuss it possible mechanism of action. Methods Totally 24 12-week old male SHR were randomly divided into SHR model group, Compound Uncaria Hypotensive Tablets group, and positive medicine group, with 8 rats in each group. Another 8 WKY rats were set as normal control group. Medication groups were given relevant medicine for gavage for successive 6 weeks. Noninvasive tail cuff method was used to observe blood pressure; morphological changes in thoracic aorta and renal artery were observed by HE staining; immunohistochemistry was used to detect the protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Results Protein expressions of MCP-1 and MMP-9 in thoracic aortic wall of SHR model group were significantly higher than those of normal control group (P<0.01); Compared with the SHR model group, protein expressions of MCP-1 and MMP-9 in thoracic aortic wall decreased significantly in the medication groups (P<0.05, P<0.01); Compared the Compound Uncaria Hypotensive Tablets group and positive medicine group, there was no obvious difference in protein expressions of MCP-1 and MMP-9 in thoracic aortic wall. Conclusion Compound Uncaria Hypotensive Tablets can reduce the blood pressure of SHR, reduce inflammation reaction, and regulate vascular remodeling, which mechanism may be related to down-regulation of expressions of MCP-1 and MMP-9 in SHR aortic endothelial cells.
