A study of risk factors of mortality in 142 patients with severe sepsis and septic shock

VernacularTitle:严重感染和感染性休克患者死亡的危险因素分析
Author: Lei HUANG ; Weixing ZHANG ; Yingqun CHEN ; Sheng ZHANG ; Jingying CHEN ; Weijia LI ; Xiaohan CHANG
Publication Type:Journal Article
Keywords: Infection; Shock; Mortality; Risk factor
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(19):2969-2972
CountryChina
Language:Chinese
Abstract: Objective To study the risk factors of mortality in severe sepsis and septic shock patients. Methods 142 patients with severe sepsis and septic shock in ICU were observed and divided into alive group (98 patients)and dead group (44 patients)by using hospital mortality.The risk factors of mortality in severe sepsis and septic shock patients were assessed by binary logistic regression.Results Independent mortality risk factors were inotropic agents (OR =4.329,95%CI:1.045 -17.937,P =0.043),blood glucose >10 mmol/L (OR =3.771,95%CI:1.214 -11.710,P =0.022)and APACHE Ⅱ score (OR =3.098,95%CI:2.012 -4.760,P =0.000),while PaO2 /FiO2 after early goal -directed therapy (EGDT)was protective factor (OR =0.682,95%CI:0.500 -0.930, P =0.016).Conclusion Severe sepsis and septic shock patients with inotropic agents,blood glucose >10mmol/L, high APACHE Ⅱ score and decreased PaO2 /FiO2 after EGDT indicate poorly prognosis.