The relationship between homocysteine expression and diabetic nephropathy patients with type 2 diabetes

VernacularTitle:同型半胱氨酸在2型糖尿病肾病患者血液中的表达及相关性研究
Author: Hongdan BAO ; Yuyu ZHU ; Yafen ZHOU
Publication Type:Journal Article
Keywords: Hcy; Diabetic nephropathy
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(19):3011-3013
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between homocysteine (Hcy)expression and diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM).Methods 100 cases with T2DM were selected,they were divided into observation group(diabetic early nephropathy,n =50)and matched group(simple diabetes,n =50),50 healthy people were involved as control group.Hcy,BUN and Cre were detected and compared among groups. Results Hcy level in 3 groups showed a increased trend,there were significant differences among groups (F =145.007,P <0.01).Hcy level of the control group was (8.19 ±0.92)μmol/L,which was significantly lower than that in the observation group and matched group[(9.63 ±1.15)μmol/L (P <0.01)and (11.94 ±1.24)mmol/L (P <0.01)].There were no significant differences of levels of BUN and Cre among the groups (F =0.66,P >0.05),the comparison between groups also had no statistical significance (P =0.936,0.097,all P >0.05 ). Conclusion Hcy may participate in the process of early type 2 diabetic nephropathy,can be used as important reference index of diagnosis of early diabetic nephropathy.