Changes of coagulation and fibrinolysis function and PLT in patients with lung cancer before and after ;chemotherapy
10.3760/cma.j.issn.1008-6706.2016.19.035
- VernacularTitle:肺癌患者化疗前后凝血、纤溶功能相关指标和血小板计数变化分析
- Author:
Jianhua ZHU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Blood coagulation factors;
Fibrinogen;
Pyrimidine dimers;
Platelet count
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(19):3014-3017
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of blood coagulation and fibrinolytic function and PLT in patients with lung cancer before and after chemotherapy,and to investigate the changes of the patients with lung cancer and the influence of the changes with lung cancer and the prognosis.Methods 40 patients with lung cancer(observation group)treated in our department from March 2012 to May 2014 were selected as the research subjects.The changes of coagulation and fibrinolytic activity,PT(PTINR),APTT,thrombin time(Fib),thrombin time(D -D),thrombin time (TT),D -D,and PLT were analyzed.The relationship between the parameters and the lung cancer staging was analyzed. Results Before chemotherapy,the levels of Fib,PLT,D -D,PT,PTNR,APTT,TT,PLT were (11.34 ±1.14)s, (1.01 ±0.07),(24.34 ±4.53)s,(2.54 ±0.45)g/L,(184.31 ±10.88)×109 /L,(143.35 ±23.45)ng/mL, (14.55 ±4.56)s.After chemotherapy,the levels of Fib,PLT,D -D,PT,PTNR,APTT,TT,PLT were (11.57 ± 1.36)s,(1.03 ±0.05),(24.52 ±5.32)s,(3.63 ±0.65)g/L,(210.45 ±11.24)×109 /L,(126.56 ±26.55)ng/mL, (14.34 ±4.17)s.The contents of Fib and PLT after chemotherapy were higher than before chemotherapy(t =0.024, 0.025,all P <0.05),D -D decreased(t =0.001,P <0.05),PT,PTNR,APTT,TT had no statistically significant changes(P >0.05).Compared with patients with stage Ⅰ ~Ⅱ lung cancer,Fib level in stage Ⅲ ~Ⅳ lung cancer was higher (t =0.01,P <0.05),and the rest of the patients with stage III and IV lung cancer had no significant difference.After chemotherapy,D -D decreased group(38 cases),which effective in 28 cases,10 cases were ineffec-tive.D -D increased group(n =42)effective in 12 cases,invalid in 30 cases,the difference between two groups was statistically significant (Z =-4.236,P =0.003).Chemotherapy effective group and ineffective group PT,PTINR, APTT,Fib,T -T and PLT had no statistically significant differences (all P >0.05).Conclusion PLT and Fib were increased,but D -D decreased after chemotherapy,the tumor remission rate was higher in D -D group,which indica-ted that the levels of Fib and D -D should be changed in the course of clinical chemotherapy.
