Effects of Qingshen Granules on Life Quality of Chronic Kidney Disease Patients with Damp-heat Syndrome
10.3969/j.issn.1005-5304.2016.10.007
- VernacularTitle:清肾颗粒对慢性肾脏病湿热证患者生存质量的影响
- Author:
Hua JIN
;
Yiping WANG
;
Yong LV
;
Kejun REN
;
Ling WEI
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
Qingshen Granules;
chronic kidney disease;
damp-heat syndrome;
life quality
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(10):26-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the improvement effects of Qingshen Granule on the life quality of chronic kidney disease (CKD) patients with damp-heat syndrome. Methods The CKD patients with damp-heat syndrome were randomly divided into experimental group and control group. The control group was treated with Western medicine, and the treatment group was treated with Qingshen Granules additionally for 12 weeks. SCr and eGFR were observed before and after treatment, and the life quality was investigated by KDQOL-SFTM1.3. Results Actually 156 cases were completed, including 77 cases in the treatment group and 79 cases in the control group. The total rate of curative effect was 81.82% (63/77) in teatment group, and (63.29%, 50/79) in control group, with significent difference (P<0.05). Multivariate linear regression analysis indicated that gender, education level, TCM syndrome score, CKD stage, eGFR and Hb level could affect the life quality. The scores of KDQOL-SFTM and its containing the MOS item short from health survey (SF-36) and kidney disease targeted areas (KDTA) were significantly improved after treatment in experimental group (P<0.05), while the scores in control group were with no significant improvement. The improving effects of PCS, and SPL, SLEEP, PS in KDTA in treatment group were significantly superior to those in control group (P<0.05). The scores of life quality in effective and stable cases increased significantly after treatment compared with before treatment (P<0.05). Conclusion Qingshen Granules can effectively improve the life quality of CKD patients with damp-heat syndrome, and the effect is not dependent on the improvement of laboratory indexes (renal function).
