The effect ofShaoyao-Gancao grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone
10.3760/cma.j.issn.1673-4246.2016.09.007
- VernacularTitle:芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响
- Author:
Shanshan XIE
;
Yaqing CHEN
;
Zhengyuan NING
;
Liyan YU
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Hyperprolactinemia;
Risperidone;
Shaoyao-Gancao grain;
Prolactin;
Positive and negative syndrome scale
- From:
International Journal of Traditional Chinese Medicine
2016;38(9):790-792
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Shaoyao Gancao Grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone.Methods 100 patients were randomly divided into the control group 50 cases,which were given risperidone. The study group 50 cases,which were given Shaoyao Gancao Grain on the basis of the control group. The two groups were treated for 12 weeks. Positive And Negative Syndrome Scale,serum prolactin and Estrogen level were measured by immunohistochemistry before and after 12 weeks of treatenmt.Results After 12 weeks of treatenmt,serum prolactin levels were decreased in the study group than control group (46.28 ± 14.06 ng/mlvs. 117.89 ± 22.11 ng/ml;t=10.242,P<0.01). PANSS score were decreased in the study group copare with before treatenmt (67.45 ± 7.00vs. 96.53 ± 11.88;t=7.125,P<0.01). PANSS score were decreased in the control group copare with before treatenmt (68.73 ± 7.71vs. 9 7.93 ± 12.65;t=6.541,P<0.01). But there were no difference in PANSS score between the two groups after treatenmt (t=0.682,P>0.05). ConclusionsShaoyao-Gancao grain can decrease serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone,does not affect estrogen levels.
