The effect ofJiuwei-Sanjie capsuls combined with levothyroxine sodium on IL-17 and IL-23 expression in the patients with Hashimoto’s thyroiditis
10.3760/cma.j.issn.1673-4246.2016.09.009
- VernacularTitle:九味散结胶囊结合左甲状腺素钠对桥本甲状腺炎IL-17和IL-23表达的影响
- Author:
Daoliang OU
;
Zhongwen LI
- Publication Type:Journal Article
- Keywords:
Thyroiditis,autoimmune;
Jiuwei-Sanjie capsul;
Levothyroxine sodium;
Immunomodulation;
Interleukin-17;
Interleukin-23
- From:
International Journal of Traditional Chinese Medicine
2016;38(9):796-799
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect ofJiuwei-Sanjie capsuls combined with levothyroxine sodium on IL-17 and IL-23 expression in the patients with Hashimoto’s thyroiditis (HT). Methods A total of 76 HT patients were randomly divided into the control group (n=38) and observation group (n=38). The control group was treated with Levothyroxine Sodium, and the observation group was treated with Levothyroxine Sodium andJiuwei-Sanjie capsuls. The expression of FT3, FT4, TSH, TGAb, and TPOAb were detected by chemiluminescent immunoassay. The expression of IL-17 and IL-23 were detected by ELISA analysis. The clinical effect were compared.ResultsThe clinical effect was 94.7% (36/38) in observation group, which was better than that of 81.6% (31/38) in control group (χ2=2.316,P=0.042) . After treatment, the expression of IL-17 (22.32 ± 4.25 ng/mlvs. 31.55 ± 6.84 ng/ml,t=2.416) and IL-23 (14.72 ± 3.42 ng/mlvs. 23.27 ± 5.26 ng/ml, t=2.512) in observation group was lower than that in control group (P<0.05). The expression of TSH (3.04 ± 0.82 IU/mlvs. 4.83 ± 1.22 IU/ml,t=2.355), TGAb (152.71 ± 38.02 IU/mlvs. 238.48 ± 54.18 IU/ml,t=2.406), and TPOAb (121.31 ± 26.23 IU/mlvs. 184.19 ± 42.53 IU/ml,t=2.423) in observation group was lower than that in control group after treatment (P<0.05).ConclusionsJiuwei-Sanjie capsuls can decrease IL-17 and IL-23
expression in patients with Hashimoto's thyroiditis, and improve thyroid function.
