Serum vancomycin concentration distribution and its clinical therapeutic effect on children with severe Gram-positive cocci pneumonia

VernacularTitle:万古霉素治疗儿童革兰阳性球菌重症肺炎血药浓度与疗效分析
Author: Xin ZOU ; Guangli ZHANG ; Gan ZHOU ; Ming CHEN ; Qingqing MENG ; Xiaoyin TIAN ; Wei WANG ; Yuntao JIA ; Zhengxiu LUO
Publication Type:Journal Article
Keywords: severe pneumonia; vancomycin; serum concentration; clinical therapeutic effect; child
From: Journal of Clinical Pediatrics 2016;34(8):570-574
CountryChina
Language:Chinese
Abstract: Objective To analyze the characteristics of serum vancomycin concentrations and its clinical therapeutic effects. Methods Serum vancomycin concentrations of 59 children diagnosed with severe Gram positive cocci pneumonia and treated with vancomycin were retrospectively analyzed. Vancomycin concentrations, biochemical values and disease status of patients were analyzed. Results The serum vancomycin concentrations of severe Gram positive cocci pneumonia children accompanied by acyanotic congenital heart disease was significantly higher than those without congenital heart disease, ( 12 . 12 mg/L vs 7 . 76 mg/L, P=0 . 008 ). The therapeutic effect of 40-60 mg/(kg·d) dosage group was signiifcantly higher than that of?60 mg/(kg·d) dosage group. Acute liver function damage and moderate/severe anemia may be risk factors for poor therapeutic effects to severe Gram positive cocci pneumonia children (P?