Analysis of screening and therapeutic effect of congenital hypothyroidism
10.3969/j.issn.1000-3606.2016.08.010
- VernacularTitle:先天性甲状腺功能减低症筛查及治疗效果分析
- Author:
Xiuli WANG
;
Lei PENG
;
Danyan YANG
;
Jiao WU
- Publication Type:Journal Article
- Keywords:
congenital hypothyroidism;
intelligence development;
neonatal screening
- From:
Journal of Clinical Pediatrics
2016;34(8):602-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore neonatal screening and therapeutic effects of congenital hypothyroidism (CH) in Xuzhou. Methods Data of neonatal heel blood thyroid stimulating hormone (TSH) tested with time-resolved lfuoroimmunoassay from July 2003 to July 2015 were retrospectively analyzed; The cases with positive screening tests were called back for further examination of the serum thyroid function (TSH,FT 3,FT 4 ) by chemiluminescence immunoassay method. The CH patients were given levothyroxine replacement. A total of 686 patients with CH treated routinely for 1 years later (CH group) and 650 matched healthy children (control group) were included in the study. The physical development was monitored regularly. The neurodevelopment was tested at 1 and 3 years old. Results In Xuzhou 1228289 neonates were screened during 12 years,of them 950 cases were diagnosed with CH and the incidence was 1/1293 . Among 635 CH patients who received treatment and follow-up regularly for 2 years,?488 cases ( 76 . 85%) were evaluated to have permanent hypothyroidism and 147 cases ( 23 . 15%) have transient hypothyroidism. There were no signiifcant differences in developmental quotient between the CH group and the control group at 1 and 3 years old (P?>?0 . 05 ). Conclusions Neonatal disease screening is an effective measure for early diagnosis of CH; the physical and mental development are normal in CH patients after early replacement therapy.
