Guidance significance of NT-proBNP concentration change in middle and long term rational control of blood transfusion and fluid infusion volume in patients with severe burn
10.3969/j.issn.1673-4130.2016.16.008
- VernacularTitle:NT-proBNP浓度改变对重度烧伤患者中长期合理控制输血补液量的指导意义
- Author:
Lei DING
;
Bei WANG
;
Qingtai ZHOU
;
Liping XU
;
Chuanlu REN
- Publication Type:Journal Article
- Keywords:
burn;
NT-proBNP;
blood transfusion;
fluid infusion;
warning
- From:
International Journal of Laboratory Medicine
2016;37(16):2226-2228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of NT‐proBNP concentration and the fluid infusion volume in the patients with severe burn ,and to evaluate the significance of monitoring NT‐proBNP in severe burn patients .Methods Fifty cases of severe burn in 100 Hospital of PLA form September 2012 to September 2015 were selected ,without major disease history and genetic history before admission ,among them ,25 cases(group A) had the burned area 35% -50% TBSA or Ⅲ degree 10% -20% TBSA ,18 cases (group B) had the total burn area of >50% TBSA or Ⅲ degree >20% TBSA for group B and 10 cases(group C) had the total burn area>90% and were composite explosive injury .The NT‐proBNP concentrations were monitored on 1-30 d after admission for guiding blood transfusion and fluid infusion;contemporaneous age‐matched 53 patients with plastic surgery were selected as the control group .Compared with the calculation formula of the fluid volume ,the guiding advantage of NT‐proBNP was analyzed .Re‐sults The practical fluid volume in these burn patients were higher than that calculated by the common fluid replacement formula . The more severe burn ,the higher the NT‐proBNP concentration and the more blood products were demanded;the NT‐proBNP con‐centration ,fluid infusion volume ,MAP infusion volume and PLT transfusion volume had statistical difference between the group C and B and between the group B and A (P<0 .05) .Conclusion The NT‐proBNP concentration change may have a higher guidance and early warning significance for middle and long term rational control of blood transfusion and fluid infusion volume in the pa‐tients with severe burns .
