Expression of taurine up-regulated gene 1 and the clinical significance in renal cell carcinoma
10.3760/cma.j.issn.1008-6315.2016.09.003
- VernacularTitle:牛磺酸上调基因1在肾癌组织的表达及临床意义
- Author:
Jing QUAN
;
Lu JIN
;
Xiang PAN
;
Yaoting GUI
;
Shangqi YANG
;
Xiangming MAO
;
Yongqing LAI
- Publication Type:Journal Article
- Keywords:
Renal cell carcinoma;
Tumor stage;
Long non-coding RNA;
Taurine up-regulated gene 1
- From:
Clinical Medicine of China
2016;32(9):776-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression level of Taurine up?regulated gene 1( TUG1) in the re?nal cell carcinoma and paired paracancerous normal tissues,then explore the relationships between the expression level of TUG1 and clinical characteristics.Methods RNA was Extacted from the resected renal cell carcinoma tissues and paired paracancerous normal tissues of 46 patients respectively,by reverse transcription to get cDNA, the expression level of the TUG1 was detected by RT?qPCR, the relationship between the expression level of TUG1 and the clinicopathological characteristics was analyzed by statistically software. Results The expression of TUG1 in renal cell carcinoma was obviously lower than that in paired paracancerous normal tissues(0.533±0. 027 vs. 1.000±0.298,t=-3.350,P<0.01).The△CT value of Tug1 in 46 cases of renal cell carcinoma after log?arithmic transformation,the minimum value was -5.535,maximum was 3.085,average value was -0.908,with the average of -0.908 as a dividing line,46 cases of renal cell carcinoma with 25 cases (54.34%) were down regulated the expression.The expression level of TUG1 of patients with renal carcinoma have no significant corre?lation with age,sex,type of renal cell carcinoma,TNM staging and UICC/AJCC staging(P>0.05).Conclusion The expression of TUG1 in renal cell carcinoma tissues are down?regulated,which also suggest that it may be re?lated to the tumorigenesis and development of renal cell carcinoma.
