Predictive value of spleen-liver volume ratio on the prognosis of partial hepatectomy in patients with hepatocellular carcinoma
10.3760/cma.j.issn.1008-6315.2016.09.012
- VernacularTitle:肝癌患者术前脾肝体积比对肝部分切除术预后的预测价值
- Author:
Guanning LI
;
Zhenhuai YANG
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Partial hepatectomy;
Spleen-liver volume ratio;
Prognosis
- From:
Clinical Medicine of China
2016;32(9):807-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of spleen?liver volume ratio( SLVR) on the prog?nosis of partial hepatectomy in patients with hepatocellular carcinoma. Methods Clinical data of 86 cases of hepatocellular carcinoma underwent hepatectomy who were treated in the Traditional Chinese Medicine Hospital of Guangzhou from January 2009 to December 2014 were analyzed retrospectively. According to the preoperative spleen?liver volume ratio,these patients were divided into 2 groups:those with SLVR<0. 8 as low SLVR group with 44 cases, and SLVR ≥0. 8 as high SLVR group with 42 cases. Patients were followed?up until June 2015. Cox ratio risk pattern analysis was used for the recurrent correlative factors. Results The 1,3,5 year sur?vival rates of low SLVR group were 95. 5%, 88. 6%, 81. 8%, of the high SLVR group were 73. 8%, 47. 6%, 40. 5%,the differences between two group were statistically significant (χ2 = = 10. 223, 16. 098, 18. 010, P<0. 05) . Univariate analysis showed that,the maximum diameter of the tumor>5 cm,the number of tumor>3,por?tal vein or hepatic vein tumor thrombus,preoperative AFP?L3%≥10%,the rate of Invasion of blood vessels and the percentage of positive margins of high SLVR group all significantly lower than that of low SLVR group (25. 0%(11/44) vs. 59. 5%(25/42),22. 7%(10/44) vs. 54. 8%(23/42),9. 1%(4/44) vs. 26. 2%(11/42),38. 6%(17/44) vs. 78. 6%(33/42),18. 2%(8/44) vs. 38. 1%(16/42),2. 3%(1/44) vs. 14. 3%(6/42);χ2=20. 645,16. 180,24. 728,4. 819,18. 402,20. 105;P<0. 05) . Cox regression analysis revealed that di?ameter of the tumor>5 cm,SLVR ≥0. 8,AFP?L3≥10%,and portal vein or hepatic vein tumor thrombus were independent predictors of poor disease?free survival after hepatectomy for hepatocellular carcinoma( Or=6. 141, 3. 753,6. 968,7. 763;P<0. 05). Conclusion Preoperative SLVR ≥0. 8 is an independent adverse predictor of poor disease?free survival,can preliminarily predict the prognosis of patients with hepatocellular carcinoma.
