Expression of C-erbB-2 in sinonasal squamous cell cancer cells and its significance
10.7644/j.issn.1674-9960.2016.08.011
- VernacularTitle:C-erbB-2在鼻腔、鼻窦鳞状细胞癌组织中的表达及其意义
- Author:
Honglue LU
;
Jianli ZHANG
;
Fei KANG
- Publication Type:Journal Article
- Keywords:
nasal cavity neoplasms;
paranasal sinus neoplasms;
carcinoma,squamous cell;
C-erbB-2
- From:
Military Medical Sciences
2016;40(8):665-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expressions and clinical significance of human epidermal growth factor receptor-2 (C-erbB-2) protein in sinonasal squamous cell cancer cells.Method Immunohistochemical and RT-PCR methods were used to detect the expression of C-erbB-2 in 62 cases of sinonasal squamous carcinoma tissues,30 cases of nasal polyps and 25 cases with normal nasal mucosa.The relationships between the expression of C-erbB-2 in sinonasal squamous carcinoma tissues and clinical pathological characteristics were analyzed.Results There was significant difference in the expression of C-erbB-2 in sinonasal squamous carcinoma tissues, nasal polyps and normal nasal mucosa tissues(P <0.05).The expression of C-erbB-2 was positively correlated with the clinicopathologic stage, tumor classification and lymph node involvement(P<0.05).Conclusion The expression of C-erbB-2 is correlated with tumorigenesis,invasion and metastasis of sinonasal squamous cell carcinoma.It can be used as an auxiliary diagnostic and prediction maker as well as a new therapeutic target of sinonasal squamous cell cancer.
