Effect analysis of aspirin combined with clopidogrel therapy in patients with transient ischemic attack/light stroke
10.3760/cma.j.issn.1008-6315.2016.09.008
- VernacularTitle:阿司匹林联合氯吡格雷治疗短暂性脑缺血发作／轻型脑卒中的临床效果分析
- Author:
Hongyi LI
;
Min ZHANG
- Publication Type:Journal Article
- Keywords:
Transient ischemic attack;
Light stroke;
Aspirin;
Clopidogrel;
Antiplatelet;
effect
- From:
Clinical Medicine of China
2016;32(9):794-797
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical effect of aspirin combined with clopidogrel therapy in pa?tients with transient ischemic attack( TIA)/light stroke. Methods One hundred and forty?eight cases with tran?sient ischemic attack/light stroke were divided randomly and voluntarily into the control group( n=74) and ob?servation group( n=74) . The patients of the control group were given aspirin based on conventional treatment while the observation group were given clopidogrel based on control group treatment. The serum C?reactive pro?tein(CRP),incidence of early neurologic deterioration(END),recurrence rate within 90 days,degree of nerve function defect score (NIHSS score),clinical effect after treatment and the complications during treatment be?tween the two groups were compared. Results After one week treatment,the serum CRP level of observation group decreased obviously compared with pre?treatment ( ( 6. 24 ± 1. 63 ) mg/L vs. ( 12. 03 ± 2. 46 ) mg/L , t=5. 625,P=0. 027),and the control group((9. 34±1. 24) mg/L,t=4. 348,P=0. 036),and there was not sig?nificantly reduced in the control group( t=2. 647,P=0. 186) . The incidence of END and recurrence rate within 90 days of observation group were evidently lower than that of control group(6. 76%(5/74) vs. 21. 62%(16/74) ,1. 35%( 1/74) vs. 8. 12%( 6/74);χ2=6. 737,5. 742,P=0. 022,0. 029) . The NIHSS score at 2 weeks af?ter treatment of observation group evidently lower than that of control group,the differences were statistically sig?nificant((2. 31±1. 03) points vs. (5. 34±1. 25) points;t=4. 663,4. 928). The effective rate of observation group was obviously higher than that of control group,the differences were statistically significant(93. 24% vs. 63. 51%,χ2=6. 253,P=0. 029) . There was no statistically significant differences about complications during treatment in both groups. Conclusion Aspirin combined with clopidogrel therapy can obviously improve nerve function,reduce progress of stroke and improve the clinical effect in patients with transient ischemic attack/light stroke,it is worth popularization and application.
