Forensic clinical significance of detecting the serum levels of IL-6 and TNF-αin patients with intracranial haemorrhage
10.13618/j.issn.1001-5728.2016.04.015
- VernacularTitle:颅内出血患者血清IL-6、TNF-α变化在法医临床鉴定中的意义
- Author:
Yunxiu BAI
;
He BAI
;
Dan CHAI
;
Guoduong JIN
;
Yujia CUI
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
forensic clinical medicine;
serum;
IL-6;
TNF-α;
intracranial hemorrhage
- From:
Chinese Journal of Forensic Medicine
2016;31(4):379-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of detecting serum levels of IL-6 and TNF-α in patients with intracranial hemorrhage.Methods The serum levels of IL-6 and TNF-α in different period were detected in patients with intracranial hemorrhage, by enzyme-linked immunosorbent assays (ELISA), and compared with those of healthy subjects (the control group).ResultsThe serum levels of IL-6, TNF-α in the severe and slight patients of study group on 1st, 3rd, 5th and 7th were signiifcantly higher than those in the control group (all withP<0.05). The serum levels of IL-6, TNF-α in the severe patients of study group were signiifcantly higher than those in slight patients of study group (all withP<0.05) on 5th and 7th. The serum levels of IL-6 and TNF-α in dead cases on 5th, 7th days admission were significantly higher than those in survival cases (P<0.05). The serum levels of IL-6 was positively correlated with TNF-α (r=0.721,P<0.05).Conclusion The detection of dynamically serum levels of IL-6 and TNF-α is of great clinical value for assessing the disease development therapeutic efifcacy and prognosis of brain injury patient with intracranial hemorrhage.
