The study on the relationship between the 1h-proton magnetic resonance spectroscopy and cognitive im-pairment in patients with general paresis of the insane
10.3969/j.issn.1002-0152.2016.07.005
- VernacularTitle:麻痹性痴呆患者磁共振波谱与认知障碍的相关研究
- Author:
Haishan SHI
;
Xiaomei ZHONG
;
Le HOU
;
Xinni LUO
;
Xinru CHEN
;
Sha LIU
;
Dong ZHENG
;
Yuping NING
- Publication Type:Journal Article
- Keywords:
General paresis of insane;
Hippocampus;
Hydrogen proton magnetic reasonance spectroscopy
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(7):406-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective We aimed to use 1H-MRS to characterize metabolite concentrations in the bilateral hippo?campus in GPI patient. Methods Metabolite ratios in the bilateral hippocampus were compared between patients with GPI (n=52) and Normal Control (NC) (n=38). Clinical neurological tests were measured in all subjects and were correlat?ed to the metabolite concentrations. Results The GPI patients showed significantly lower concentrations of N-acetylas?partate(NAA)/creatine(Cr) ratios in the bilateral hippocampus region compared to the NC subjects. There was significant?ly difference in the NAA/Cr ratios between the mild GPI dementia and the severe GPI dementia groups on the left hippo?campus region. We found that the NAA/Cr ratios concentrations were positively correlated with Mini Mental state Exami?nation (MMSE) and Montreal Cognitive Assessment scale (MoCA) scores in the left hippocampus region and the mI/Cr ra?tios concentrations were positively correlated. Conclusions GPI Patients have neuronal dysfunction in the bilateral hippo?campus. The severity of cognitive impairments is associated with the severity of the damage in the left side.
