The effect of low-dose aripiprazole addition therapy on adiponectin and leptin in schizophrenia patients with olanzapine-induced weight gain
10.3969/j.issn.1002-0152.2016.07.006
- VernacularTitle:阿立哌唑联合治疗对奥氮平治疗后体重增加的精神分裂症患者脂联素和瘦素水平影响
- Author:
Yichen LI
;
Jun MA
;
Hanming XU
;
Guangyuan YANG
;
Juncheng ZHANG
- Publication Type:Journal Article
- Keywords:
Aripiprazole;
Olanzapine;
Schizophrenia;
Adiponectin;
Leptin
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(7):410-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of aripiprazole addition therapy on adiponectin and leptin in schizophrenia patients with olanzapine-induced weight gain. Methods Schizophrenia patients with clinically significant weight gain induced by olanzapine were randomly divided into two groups:treated with olanzapine+aripiprazole (5 mg/d, n=48) or olanzapine+placebo (n=46). The level of FBS, TG, TC, adiponectin, leptin, the body index (BMI) and the insu?lin resistance index (HOMA-IR) were measured before and 4, 8 and 12 weeks after treatment. Results Adiponectin in?creased and leptin as well as HOMA-IR decreased in olanzapine+aripiprazole group after 4, 8 and 12 weeks treatment (P<0.05). However, FBS, TG and TC decreased and BMI increased only after 8 and 12 weeks treatment(P<0.05). In olanzapine+placebo group, the dadiponectin decreased and leptin, HOMA-IR as well as BMI increased after 8 and 12 weeks treatment(P<0.05). In olanzapine + aripiprazole group the adiponectin, leptin and HOMA-IR of 4, 8 and 12 weeks and BMI of 8 and 12 weeks were different from olanzapine + placebo group(P<0.05). Conclusions In schizo?phrenia patients with olanzapine-induced weight gain, aripiprazole addition therapy can ameliorate the HOMA-IR and BMI probably through the regulation of adiponectin and leptin.
