The study on the association of blood pressure variability with early neurological deterioration in patients with acute non-cardioembolic ischemic stroke
10.3969/j.issn.1002-0152.2016.06.008
- VernacularTitle:非心源性脑梗死患者急性期血压变异与早期神经功能恶化的相关性研究
- Author:
Zhu SHI
;
Shuen LI
;
Ruilan LI
;
Weicheng ZHENG
- Publication Type:Journal Article
- Keywords:
Blood pressure;
Stroke;
Early neurological deterioration
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(6):357-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between 24-hour blood pressure variability after admission and early neurological deterioration in patients with acute non-cardioembolic ischemic stroke.Methods This was a case-control study.Patients with acute non-cardioembolic ischemic stroke within 72 hours after stroke onset were prospectively registered.Clinical and 24 -hour continuous blood pressure monitoring data were recorded, and subsequently compared with regard to whether early neurological deterioration ( END) occurred within 7 days after admission.Factors contributing to END were investigated by logistic regression model.Results Of 221 eligible patients, 59 cases ( 26.7%) exhabited END.Patients with END had higher 24-hour mean systolic blood pressure ( SBP) (145.8 ±18.2 mmHg vs.139.9 ± 20.3 mmHg, P=0.014) and SBP coefficient of deviation (SBP-CV) [9.0(7.3 -11.2) vs.8.4(6.9-10.2), P=0.011].After adjusting for crude variables, multivariate analysis showed that the increase in mean SBP (10 mmHg mean SBP,OR=1.285,95%CI(1.059~1.559) and SBP-CV [1 unit of SBP-CV, OR=1.206,95%CI(1.050~1.384)] was associated with higher risk of END.Conclusions Increased 24-hour blood pressure variability after admission is an independent risk factor for occurrence of END in patients with acute non-cardioembolic ischemic stroke.
