Transforming growth factor-beta and muscle regulation
10.3969/j.issn.2095-4344.2016.33.016
- VernacularTitle:转化生长因子β信号与肌肉调控
- Author:
Jinyue WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(33):4979-4984
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:Transforming growth factor-βsignaling widely existing in cel s mediates cel growth, proliferation, migration, differentiation, and apoptosis. The activation of transforming growth factor-βsignaling can result in muscular dystrophy. However, there have been some contradictions regarding the effects of the transforming growth factor-βsignaling on muscular dystrophy. OBJECTIVE:To summarize the latest progress in the effects of the transforming growth factor-βsignaling on muscle mass and function regulation to provide the solutions for the treatment of muscular dystrophy. METHODS:A computer-based online search was conducted in PubMed and Wanfang databases from 2005 to 2015 to screen the relevant literatures using Chinese and English key words“transforming growth factor-β, muscle, regulation mechanism, treatment”. A total of 102 literatures were retrieved, and 22 eligible literatures were included, summarized, and analyzed. RESULTS AND CONCLUSION:The activation of transforming growth factor-βsignaling as a common cause of most muscle disorders promotes the activation of muscle satel ite cel s, differentiation of myocytes, myoblast infusion, the expression of muscle-specific proteins, and the inhibition of col agen synthesis, which facilitates muscular fibrosis and scar formation. Transforming growth factor-βsignaling is involved in Duchenne muscular dystrophy, spinal scoliosis, type I diabetes induced skeletal muscle regenerative disorders, myocardial and cardiac remodeling. The inhibition of transforming growth factor-βsignaling may result in incomplete muscle recovery.
