Experimental Study on Therapeutic Effects of Xileisan Pessary on Rats with Cervicitis
10.3969/j.issn.1005-5304.2016.09.020
- VernacularTitle:锡类散栓剂对大鼠宫颈炎治疗作用的实验研究
- Author:
Qian WU
;
Renyun CUI
;
Tuo TUO
;
Yi XIAO
;
Ling HUANG
;
Yuyue LIU
;
Jinlin LIU
;
Tianlong MU
;
Yanshu PAN
- Publication Type:Journal Article
- Keywords:
Xileisan;
perssary;
cervicitis;
treating different diseases with the same therapy;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(9):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effects of Xileisan Pessary on rats with cervicitis based on the idea of treating different diseases with the same therapy. Methods Vagina perfusion of hydroxybenzene mucilage was used to establish rat cervicitis models. Rats were randomly divided into normal group, model group, positive medicine group, low-, medium-, and high-dose Xileisan Pessary groups. Rats with cervicitis were treated with Xileisan Pessary from the next day after modeling for 10 days. The amount of neutrophilic granulocytes and leukocytes were detected by blood routine analysis meter; cervial histopathologic examination was conducted by HE staining. Results Compared with normal group, the numbers of granulocyte and leucocyte increased significantly in the model group (P<0.01). Compared with the model group, the numbers of granulocyte and leucocyte in the low-dose Xileisan Pessary group showed a decreasing trend (P<0.05, P<0.01); cervical inflammation mucosal epithelium and tissue necrosis were signally alleviated; granulocyte in the medium-dose Xileisan Pessary group showed a decreasing trend (P>0.05);the content of leucocyte hardly changed;granulocyte in the high-dose Xileisan Pessary group increased observably (P<0.01); the number of leucocyte showed an increasing trend (P>0.05), and the numbers of granulocyte and leucocyte in positive medicine group decreased observably (P<0.01), and cervical inflammation mucosal epithelium and tissue necrosis were also signally alleviated. Conclusion Xileisan Perssary can relieve the inflammation of cervix and repair injured mucosa. It has the function of treating different diseases with the same therapy.
