A resting-state functional magnetic resonance imagingstudy in first-episode drug-naive schizophrenia and offspring of schizophrenia patients
10.3969/j.issn.1002-0152.2016.06.005
- VernacularTitle:首发未用药精神分裂症与精神分裂症患者健康子女静息态脑功能低频振幅研究
- Author:
Ye WANG
;
Dahai WANG
;
Shengnan WEI
;
Fei WANG
;
Yanqing TANG
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Offspring of schizophrenia;
Resting state functional magnetic resonance imaging ( rs-fMRI);
Blood oxygen level dependent ( BOLD);
Amplitude of low frequency fluctuation ( ALLF)
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(6):342-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the similarities and differences in amplitude of low frequency fluctuation ( ALLF) between patients with first-episode drug-naive schizophrenia and offspring of schizophrenia patients.Methods ALFF values were estimated by measuring the Blood Oxygen Level-Dependent ( BOLD) signal using resting state function-al magnetic resonance imaging ( rs-fMRI) .The fMRI date were acquired from 23 patients with first-episode drug-naive schizophrenia (SZ), 25 offsprings of schizophrenia patients (OS) and 29 age -and gender -matched health controls ( HC) .The ALFF value of each subject was calculated by MATLAB-based DPARSF software.Results Compared with HC, the ALFF values of SZ and OS were significantly different in the left posterior part of the inferior temporal gyrus, left parahippocampal gyrus, left hippocampus, right postcentral gyrus and bilateral precuneus.The ALFF values were not signif-icantly different between these two groups in the aforementioned regions.Compared with OS and HC, the ALFF values of SZ were significantly different in the left anterior part of the inferior temporal gyrus, left temporal pole and bilateral calcarine cortex.But there was no significant difference between OS and HC.Conclusions The brain function is abnormal in pa-tients with early schizophrenia and offspring of schizophrenia patients.The significant difference of ALFF in the left posterior part of the inferior temporal gyrus, left parahippocampal gyrus, left hippocampus, right postcentral gyrus and bilateral pre-cuneus may suggest the heredodiathesis-related brain functional alterations.Significant difference of ALFF in the left ante-rior part of the inferior temporal gyrus and the left temporal pole bilateral calcarine cortex may suggest the disease-related brain alterations.
