Progress of transforming growth factor beta/bone morphogenetic protein pathway and genetic mechanisms of pulmonary arterial hypertension
10.3760/cma.j.issn.1673-4408.2016.08.001
- VernacularTitle:转化生长因子β/骨形成蛋白通路与肺动脉高压遗传学机制的研究进展
- Author:
Juan CHEN
- Publication Type:Journal Article
- Keywords:
Pulmonary artery hypertension;
Transforming growth factor beta;
Bone morphogenetic protein;
Smad;
Mitogen activated protein kinase
- From:International Journal of Pediatrics
2016;43(8):593-597
- CountryChina
- Language:Chinese
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Abstract:
Pulmonary arterial hypertension is the result of a variety of heart,lung disease and finally leads to right heart failure and death.Pulmonary arterial hypertension is characterized by the progressive increasing of artery pressure and the gradually increasing of pulmonary vascular resistance,and its pathogenesis has not been fully elucidated.Recent studies have found that transforming growth factor beta/bone morphogenetic protein pathway plays an important role in pulmonary arterial hypertension.The research about transforming growth factor betal bone morphagenetic protein pathway provides a new theoretical basis for the prevention and treatment of pulmonary arterial hypertension.This review focuses on progress of transforming growth factor beta/bone morphogenetic protein pathway and genetic mechanisms of pulmonary arterial hypertension.
