Therapeutic Effect of Compound Fanshiliu Recipe for Over-weighted Type 2 Diabetes Mellitus
10.13359/j.cnki.gzxbtcm.2016.05.003
- VernacularTitle:复方番石榴制剂治疗超重肥胖2型糖尿病的疗效分析
- Author:
Jinyan CHENG
;
Leyu LI
;
Zehong LIN
;
Tianmei XIAO
;
Ruiyan XU
- Publication Type:Journal Article
- Keywords:
Compound Fanshiliu Recipe;
overweight;
obesity;
type 2 diabetes mellitus;
clinical effect
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2016;33(5):630-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical effect of Compound Fanshiliu Recipe(CFR) for the treatment of over-weighted type 2 diabetes mellitus(T2DM). Methods One hundred and twenty over-weighted T2DM patients were randomized into treatment group and control group, 60 cases in each group. Both groups were given oral use of Metformin Hydrochloride Enteric-Coated Tablets, and additionally the treatment group was treated with CFR orally. The treatment of both groups lasted for 12 continuous weeks. Before and after treatment, we detected the waist circumference (WC), body mass index (BMI), and the levels of fasting blood glucose(FBG), postprandial 2-hour blood glucose(P2hBG), glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglyceride (TG), and free fatty acid (FFA). The therapeutic effect of the two groups was also evaluated after treatment. Results (1) The total effective rate for traditional Chinese medical symptoms was 95.00% in the treatment group, and was 70.00%in the control group, the difference being significant(P<0.01).(2) After treatment, WC and BMI were decreased in the treatment group(P<0.01 compared with those before treatment), but had no significant decrease in the control group(P>0.05). The decrease of WC and BMI of the treatment group was superior to that of the control group(P<0.05).(3) After treatment, levels of FBG, P2hBG, HbA1c, TC, TG, and FFA of both groups were significantly improved (P<0.05), and the improvement of the treatment group was superior to that of the control group(P<0.05).(4) Three patients of the treatment group suffered from slight gastric discomfort, and the discomfort was relieved without any special treatment. Other patients of the two groups had no adverse reaction. Conclusion Treatment of CFR combined with Metformin has been proved to be an effective and safe approach to decrease blood glucose and blood lipid levels, promote weight loss, and ameliorate traditional Chinese medical symptoms.
