Efficacy of entecavir and lamivudine combined with adefovir dipivoxil in the treatment of e antigen positive ;chronic hepatitis B
10.3760/cma.j.issn.1008-6706.2016.18.018
- VernacularTitle:恩替卡韦与拉米夫定联合阿德福韦酯治疗e 抗原阳性慢性乙型肝炎疗效比较
- Author:
Jingnan LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Entecavir;
Lamivudine;
Adefovir
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(18):2787-2790
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of entecavir and lamivudine combined with adefovir in treatment of patients with e antigen -positive chronic hepatitis B.Methods 72 patients with HBeAg positive chronic hepatitis B were randomly divided into group Ⅰ (36 cases)and group Ⅱ (36 cases).Group Ⅰ was treated by grace entecavir,group Ⅱ was treated with adefovir and lamivudine,two groups were treated for 24 months.The HBV -DNA negative rate,ALT recovery rate,HBeAg seroconversion rate,negative conversion rate of HBsAg,HBeAg and HBeAb conversion rate of the two groups were compared after 6 months,12 months and 24 months treatment.Results After treatment for 6 months,12 months and 24 months,the HBV -DNA negative rate,HBeAg negative conversion rate, HBeAg and HBeAb rate in the two groups had no statistically significant differences.After 6 months and 12 months treatment,the ALT recovery rates of group Ⅰ were 52.78%,83.33%,which were significantly higher than 27.78%, 38.89% of group Ⅱ,the differences were statistically significant(χ2 =4.677,14.961,all P <0.05 ).The total response rates of 6 months,12 months and 24 months after treatment were 47.22%,77.78%,88.89%,72.22%, 83.33% and 44.44%,respectively.There were no significant differences between the two groups(all P >0.05). Conclusion There is similar effect of entecavir and lamivudine combined with adefovir in treatment of patients with e antigen -positive chronic hepatitis B,which can inhibit HBV replication and improve liver function,and the security was good,but entecavir has better ALT normalization rate at early,the treatment should be selected according to clini-cal practice.
