Clinical value of HLA-B27 antigen expression in the diagnosis of ankylosing spondylitis

VernacularTitle:人类白细胞抗原 B27表达对强直性脊柱炎的诊断价值
Author: Huifang WEN
Publication Type:Journal Article
Keywords: HLA antigens; Spondylitis,ankylosing; Diagnosis
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(18):2795-2797
CountryChina
Language:Chinese
Abstract: Objective To analyze the diagnostic value of human leukocyte antigen(HLA)-B27 expression for ankylosing spondylitis.Methods 100 patients with ankylosing spondylitis were selected as the study group. 100 healthy people were selected as the control group.HLA -B27 beads enzyme immunoassay reagent kits was used to implement qualitative detection of fresh whole blood in the study group,and compared HLA -B27 positive rates of the two groups,as well as the diagnosis value of HLA -B27 antigen expression.Results The HLA -B27 positive rate of the study group was 73.00%,which was higher than 9.00% of the control group,the difference was statistically significant (χ2 =84.66,P <0.01).The diagnosis rate of the male patients was 90.91%,which was higher than 72.41% of the female patients,the difference was statistically significant (χ2 =4.35,P <0.05 ).Conclusion HLA -B27 antigen has a high value for clinical diagnosis of ankylosing spondylitis,which is worthy of promotion.