Analysis of six cases of allopurinol hypersensitivity syndrome

VernacularTitle:别嘌醇超敏反应综合征6例分析
Author: Yingjie SONG
Publication Type:Journal Article
Keywords: Allopurinol; Allopurinol hypersensitivity; Allopurinol hypersensitivity syndrome; Toxic epidermal necrolysis
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(18):2828-2830
CountryChina
Language:Chinese
Abstract: Objective To analyze the characteristics of allopurinol hypersensitivity syndrome(AH),and pro-vide reference for clinical rational drug use.Methods AH cases induced by oral allopurinol administration were col-lected by dermatologists from January 1995 to January 2015 in our hospital,and 6 cases of the AH were statistically analyzed.Results All cases of AH were male and characterized by skin lesions,fever and damage of liver and kidney function.Although promptly managed,1 case of AH was mainly systemic damaged and died of multiple organ failure and the rest of those cases recuperated.Conclusion AH is an severe complication induced by allopurinol.The clini-cal medication should be strictly monitored in accordance with the instructions to reduce the incidence of AH and ensure medication safety.