Effect of heparin and aspirin on peripheral blood PAI -I and t -PA in patients with recurrent spontaneous ;abortion
10.3760/cma.j.issn.1008-6706.2016.18.006
- VernacularTitle:低分子肝素和阿司匹林对复发性流产患者血浆纤溶酶原激活物抑制剂-1和组织型纤溶酶原活化因子水平的影响
- Author:
Shujun ZHOU
- Publication Type:Journal Article
- Keywords:
Abortion,habitual;
Aspirin;
Heparin;
Plasminogen activator inhibitor -1;
Tissue -typ plasminogen activator
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(18):2740-2743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of heparin and aspirin in the treatment of recurrent sponta-neous abortion and its influence on peripheral blood PAI -I and t -PA changes.Methods 70 patients with unex-plained recurrent spontaneous abortion were selected and divided into traditional treatment group and heparin treat-ment group according to the different treatment method.At the same time,30 cases with normal early pregnancy were selected as control group.After treatment,recorded the pregnancy outcomes and neonatal birth defects and the change of peripheral blood PAI -I and t -PA.Results The success pregnancy rates of the heparin treatment group and tra-ditional treatment group were 83.58% (28cases of 36patients in success pregnancy)and 63.46% (21cases of 34patients in success pregnancy),the difference was statistically significant(P <0.05).The level of PAI -1 of the heparin treatment group after using heparin was (0.56 ±0.26)AU /mL,which was lower than before treatment(P <0.05),while the t -PA had no significant difference(P >0.05).The levels of PAI -1 and t -PA of the traditional treatment group had no statistically significant differences compared with before treatment(all P >0.05).The differ-ence of the adverse reactions,platelet,coagulation function between the two groups were not significant (all P >0.05).Conclusion Heparin and aspirin can change the coagulation status of patients with recurrent spontaneous abortion.Heparin and aspirin in the treatment of recurrent spontaneous abortion can significantly increase the curative effect,and is safe.
