Correlation of serum TNFR level with renal function injury in patients with T2DM and normal albumin ;excretion
10.3760/cma.j.issn.1008-6706.2016.18.013
- VernacularTitle:尿微量白蛋白阴性2型糖尿病患者血清肿瘤坏死因子受体水平与肾功能损害程度相关性分析excretion
- Author:
Zhongyue SHI
;
Guiying WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Diabetic nephropathies;
Receptors,tumor necrosis factor, type Ⅰ;
Receptors,tumor necrosis factor,type Ⅱ
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(18):2768-2771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation of serum TNFR level with renal function injury in patients with type 2 diabetes mellitus (T2DM)and normal albumin excretion.Methods 90 T2DMpatients with normal albu-min excretion(24h urine albumin excretion rate <20μg/min)were divided into three groups according to the esti-mated glomerular filtration rate level:eGFR >90mL · min -1 · (1.72m2 )-1 ,eGFR 60 -90mL · min -1 · (1.72m2 )-1 and eGFR <60mL·min -1 ·(1.72m2 )-1 ,30 cases in each group.The serum TNFRs level and related clinical data were measured and analyzed statistically.Results The levels of serum TNFR1,TNFR2 were negatively correlated with eGFR(r =-0.428,-0.335,all P <0.05),and positively correlated with Scr(r =0.476,0.225,all P <0.05)in patients with T2DM and normal albumin excretion.The course of disease and the levels of BUN,Scr, CysC,α1 -MG,β2 -MG were increased as the degree of renal function injury.All these index had statistically signifi-cant differences in three groups(F =3.758,5.851,71.738,25.751,7.530,13.735,all P <0.05).Logistic regres-sion analysis showed that the levels of serum TNFR1,TNFR2 were independent risk factors for renal impairment in patients with T2DMand normal albumin excretion(OR =2.009,1.143,all P <0.05).Conclusion TNFRs may be involved in the development and progression of renal impairment,and may become a new conventional indicator for DN because of reflecting the degree of renal function injury in some extent in T2DMpatients with normal albumin excretion.
