Effect of sufentanil postconditioning on acute lung injury induced by ischemia-reperfusion of uterine in rats
- VernacularTitle:舒芬太尼后处理对子宫缺血-再灌注大鼠急性肺损伤的影响
- Author:
Gehui LI
;
Xiaolei HUANG
;
Yuantao LI
;
Xiaofei QI
;
Jing SUN
;
Xiaoguang WANG
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Uterine ischemia and reperfusion;
Acute lung injury;
Oxygen free radicals;
Inflammatory cytokines
- From:
The Journal of Clinical Anesthesiology
2016;32(8):791-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of sufentanil postconditioning on acute lung in-jury induced by ischemia-reperfusion of uterine in rats.Methods Fourty-five adult female Sprague-Dawley rats were randomly divided into 3 groups(n = 1 5 each):control group (group C),ischemia-reperfusion group (group IR)and sufentanil postconditioning group(group SPC).Group SPC received sufentanil 10 μg/kg via intraperitoneal injection before inducing reperfusion of uterine.Ischemia-reper-fusion of uterine was produced by occlusion of bilateral uterine arteries for 45 min followed by reper-fusion for 2 h in group IR and group SPC.Then the content of tumor necrosis factor-α(TNF-α),mal-odiadehyde (MDA)and superoxide dismutase (SOD)activity were measured in uterus,serum and lung tissue,lung wet to dry weight ratio (W/D),lung permeability index (LPI)were compared. Results Compared with group C,TNF-α,MDA content,W/D and LPI in uterus,serum and lung tissue were significantly increased in group IR and group SPC(P <0.05).TNF-α,MDA content,W/D and LPI in uterus,serum and lung tissue were significantly attenuated in group SPC as compared with group IR (P <0.05 ).Compared with group C,SOD activity in uterus,serum and lung tissue was significantly attenuated in group IR and group SPC (P <0.05).SOD in uterus,serum and lung tissue were significantly increased in group SPC as compared with group IR (P < 0.05 ). Conclusion Sufentanil postconditioning attenuates pulmonary injury caused by ischemia-reperfusion of uterine in rats by inhibiting the inflammatory reaction and suppressing the activation of oxyradical.
