Epigenetics-based anticancer drugs:research advances
10.13220/j.cnki.jipr.2016.04.013
- VernacularTitle:基于表观遗传学的抗肿瘤药物研究进展
- Author:
Ming WANG
;
Xue LI
;
Ziling WANG
- Publication Type:Journal Article
- Keywords:
epigenetics;
neoplasms;
DNA methyl transferase inhibitors;
histone deacetylase inhibitor
- From:
Journal of International Pharmaceutical Research
2016;43(4):658-664
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,with the completion of the Human Genome Project and the development of mapping the Human Ge?nome Methylation Variable Site Map Plan,research on epigenetics and the generation and deveopment of cancer,epigenetic treatment drugs,especially the successful clinical application of the DNA methyltransferase and histone deacetylation inhibitors in the treatment of cancer patients,epigenetic has becoming a hot spot. This article reviews the recent progress in pharmacological action of epigenetics-based anticancer drugs,it may provide some new ideas to the therapy and fundamental research of cancer.
