Association between Circulating Betatrophin Levels and Metabolic Parameters in Non-alcoholic Fatty Liver Disease Patients

VernacularTitle:非酒精性脂肪肝病患者血清betatrophin浓度及其与代谢参数的相关性
Author: Han ZHANG ; Hong CHEN ; Rongping CHEN ; Min YI
Publication Type:Journal Article
Keywords: Non-alcoholic fatty liver disease; Betatrophin; Metabolic parameters; Correlation
From: The Journal of Practical Medicine 2016;32(16):2689-2692
CountryChina
Language:Chinese
Abstract: Objective To investigate circulating betatrophin levels in non-alcoholic fatty liver disease patients (NAFLD). To explore its association with various metabolic parameters in Chinese subjects. Methods From August 2014 to April 2015 , 58 patients with NAFLD and 41 non-NAFLD control subjects with age and sex matched were enrolled in the Department of Endocrinology of Zhujiang Hospital. Results In NAFLD group, serum betatrophin concentrations significantly increased (781.96 vs. 431.89 pg/mL, P < 0.05) and associated only with HDL-cholesterol level. In normal group, betetrophin levels are associated with multiple metabolic parameters, such as fasting glucose, insulin, C peptide, HOMA-IR, QUICK index and HDL-C levels. Conclusions Serum betatrophin concentration significantly elevated in non-alcoholic fatty liver disease patients and was negatively correlated with HDL-C level (r = -0.479, P < 0.001).