Urinary L-type fatty acid-binding protein at time of nephropathy consultation predicting the value of poor outcomes in critically ill patients with early acute kidney injury
10.3969/j.issn.1006-5725.2016.15.017
- VernacularTitle:尿肝型脂肪酸结合蛋白在预测早期急性肾损伤不良结局的价值
- Author:
Jin LIU
;
Jing HOU
;
Xin CHEN
;
Hua ZHONG
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Prognosis;
Biomarkers
- From:
The Journal of Practical Medicine
2016;32(15):2477-2480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of urine L-type fatty acid-binding protein (uL-FABP) and uric neutrophil gelatinase-associated lipocalin (uNGAL), and predict the value of poor outcomes (injury progression,dialysis,or death within 7 days ) in critically ill patients with early acute kidney injury (AKI) at time of nephropathy consultation. Methods One hundred and twenty-five patients with evidence of the AKIN criteria stage1 AKI were enrolled in this study. At time of nephropathy consultation , urinary samples were collected. The levels of uL-FABP and uNGAL were measured. Each marker was assessed for its predictive value using an area under the receiver operator characteristic curves (ROC-AUC) to predict AKI prognosis. Results Twenty-eight patients developed poor outcome. It was 0.81 in ROC-AUC in uL-FABP , in,which it could be improved to 0.83 when combined with APACHEⅡscore (0.75 in ROC-AUC). The ROC-AUC of uNGAL was 0.66, in which it could not impove its predictive power significantly when combined with APACHEⅡscore. Conclusion Among critically ill patients with early AKI , uL-FABP provided an independent and prognostic power when combined with APACHEⅡscore and the level of uL-FABP at time of nephropathy consultation helps to predict clinical outcome in critically ill patients with early AKI.
