Change of glyoxalase I in type 2 diabetic ocular muscles palsy and its associations with advanced oxidation protein products and oxidative stress
10.3969/j.issn.1006-5725.2016.16.018
- VernacularTitle:血清乙二醛酶I在2型糖尿病眼肌麻痹中的意义及与晚期蛋白氧化产物及氧化应激的相关性
- Author:
Xuewen FENG
;
Haiyang LIN
;
Zhengjun CHEN
;
Weilin WU
;
Chenfeng QIU
;
Haijin ZHOU
;
Youyu JIN
;
Xianjun BAO
- Publication Type:Journal Article
- Keywords:
Diabetic ocular muscles palsy;
Glyoxalase;
Advanced oxidation protein products;
Oxidative stress
- From:
The Journal of Practical Medicine
2016;32(16):2659-2662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of glyoxalase I in type 2 diabetic ocular muscles palsy (DOMP) and its associations with advanced oxidation protein products (AOPP) and oxidative stress. Methods 58 DOMP patients, 50 T2DM and 30 normal controls were enrolled in this study. Levels of blood lipids, fasting blood glucose, hemoglobin A1c, insulin, serum glyoxalase I, AOPP, malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were measured. Homeostasis model assessment was performed to evaluate the status of insulin resistance (IR). Results Levels of high-density lipoprotein cholesterol, SOD and T-AOC were positively correlated with glyoxalase I and inversely associated to AOPP. Levels of triglycerides , low-density lipoprotein cholesterol , fasting blood glucose , hemoglobin A1c , IR and MDA were negatively correlated with glyoxalase I and positively related to AOPP. AOPP had an inverse association with glyoxalase I (r = -0.823, P < 0.001). Multivariate regression analysis showed that serum levels of glyoxalase I (Sβ = 0.554) and AOPP (Sβ= -0.469) were influencing factors of groups. Conclusion Serum glyoxalase I levels were significantly decreased in DOMP and correlated with AOPP and levels of oxidative stress , which suggest that glyoxalase I could play crucial roles on the development of DOMP.
