Efficacy and Safety of Oxcarbazepine combined with Levetiracetam on Children with epilepsy

VernacularTitle:奥卡西平联合左乙拉西坦治疗小儿癫痫的疗效及安全性
Author: Zhibin LI ; Huiming JIANG ; Hua XIAO
Publication Type:Journal Article
Keywords: Oxcarbazepine; Levetiracetam; Epilepsy
From: The Journal of Practical Medicine 2016;32(16):2734-2736
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy and safety of oxcarbazepine combined with levetirac-etam on children with epilepsy. Methods According to different treatments, 62 cases of children with epilepsy were divided into the OXC group (treated with oxcarbazepine, 40 cases) and the OXC combined with LEV group (treated with oxcarbazepine and levetiracetam, 20 cases). Then the therapeutic efficacy, EEG changes and ad-verse reactions of patients in the two groups were studied. Results The total efficacy was 87.5% in the OXC group, and was 95.5% of the OXC combined with LEV group, with no significant difference. EEG improvement rate was 52.5% in the OXC group and 81.8% in the OXC combined with LEV group , with significant difference (P < 0.05). The rate of adverse reactions in the OXC combined with LEV group was lower than that in the OXC group (P < 0.05). Conclusion Both levetiracetam and oxcarbazepine has good curative effect on children with epilepsy , but combination with levetiracetam can significantly decrease the epileptic discharges on EEG , with higher security.