Effect of ischemic postconditioning on IL-6 and ATP level during renal ischemia-reperfusion injury in obstructive jaundice rats
10.3969/j.issn.1006-5725.2016.15.006
- VernacularTitle:缺血后处理对梗阻性黄疸大鼠肾缺血再灌注损伤IL-6及ATP的影响
- Author:
Yi LI
;
Xuexia ZHANG
;
Wenying ZHOU
;
Wenhua LI
;
Qingan ZENG
- Publication Type:Journal Article
- Keywords:
Ischemic postconditioning;
Ischemia reperfusion;
Kidney;
Obstructive jaundice;
interleukin-6;
Adenosinetriphosphate
- From:
The Journal of Practical Medicine
2016;32(15):2442-2444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the apoptosis effect of ischemic postconditioning on levels of IL-6 and ATP during renal ischemia/reperfusion injury in obstructive jaundice rats. Methods One hundred SD rats were randomly divided into 5 groups: the Sham control group , I/R group , OJ-Sham group , OJ-I/R group , and OJ- I/R+IPO group, with 20 cases in each group. According to the time after ischemia/reperfusion, each group was divided into four subgroups (n = 5), with reperfusion time of 0 h, 1 h, 3 h, 6 h, respectively. After 1 week of biliary obstruction , rats were sacrificed at 0 h , 1 h , 3 h , 6 h post-I/R , and the left kidneys were taken, renal tissue was used for determination of the levels of interleukin-6 (IL-6) and adenosinetriphosphate (ATP). Results Compared with the OJ-I/R group, the serum level of BUN,Cr decreased significantly in the OJ-I/R-IPO group (P < 0.05). Conclusion Ischemic postconditioning can reduce the injury of kidney ischemia-reperfusion in OJ rais , which may be related to the reduced inflammation reaction and the energy metabolism in the kidney.
