Relationship of expressions of HIF-1α, VEGF and EGFR in esophageal squamous cell carcinoma to radiation therapy efficacy
10.3969/j.issn.1006-5725.2016.15.011
- VernacularTitle:食管鳞癌组织中HIF-1α、VEGF和EGFR的表达与放射治疗疗效的关系
- Author:
Yangyang FENG
;
Xuehong BAI
;
Ping HAI
;
Yanyang WANG
;
Ren ZHAO
;
Hong ZHE
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
HIF-1α;
VEGF;
EGFR;
Radiotherapy;
Short-term outcome
- From:
The Journal of Practical Medicine
2016;32(15):2458-2461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe into the relation of expressions of HIF-1α, VEGF and EGFR in esophageal squamous cell carcinoma with radiation therapy efficacy. Methods 73 of the patients with carcinoma of oesophagus from January , 2011 to May , 2014 in the General Hospital of Ningxia Medical University , were involved in this research , their clinical data reviewed and analyzed. Before radiotherapy , immunohistochemical SP was used to test expressions of HIF-1α, VEGF and EGFR in the cancer tissues. Relationships between the expressions and the efficiency of radiotherapy were analyzed. Results The positive expressions of HIF-1α, VEGF and EGFR were 70.0%, 84.9% and 80.8%, respectively. In terms of the single factor analysis related to recent curative effects, HIF-1α expression had significant correlation with recent curative effects (P=0.03). Conversely , multiplicity indicated that HIF-1α and EGFR expressions were notably associated with recent curative effects (P=0.007, 0.045, respectively). Conclusions The positive expressions of HIF-1α,VEGF and EGFR in the esophageal carcinoma may account for a largest proportion of the total. HIF-1α and EGFR expressions are associated with the short-term outcomes.
